Voltammetric Behavior of Degradation Product
- Release time:2024-08-09
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Affiliation of Author(s):
化学与化工学院
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Journal:
CHEM. RES. CHINESE UNIVERSITIES
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Key Words:
中文关键字：头孢地尼；降解产物；电极反应；电化学行为，英文关键字：Cefdinir; Degradation product; Electrode reaction
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Abstract:
The electrochemical behavior of the degradation product of cefdinir(CDR) was studied in a 0.05 mol/L
NaOH solution by means of linear sweep voltammetry(LSV) and cyclic voltammetry(CV). The results indicate that
the C=N bond in the oxime group was reduced. Moreover, a saturated adsorption amount of 1.32×10–10 mol/cm2 at
Hg electrode was obtained. The adsorption coefficient β was 1.56×105 L/mol. Gibbs standard energy of adsorption
ΔG0 at 25 °C was –29.63 kJ/mol and the number of electrons transferred n was 2. A method for the determination of
CDR was proposed by differential pulse voltammetry(DPV). The reduction peak currents of the CDR’s degradation
product were found to be linear in a concentration range of 4.0×10–7―4.0×10–6 mol/L and that of 4.0×10–8―4.0×10–7
mol/L, respectively. The detection limit was found to be 3.0×10–8 mol/L under the optimized conditions. The applicability
of this approach was illustrated by the determination of CDR in capsules. In addition, the mechanism about the
degradation of CDR in 0.2 mol/L NaOH was discussed by UV spectrophotometry.
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Note:
董社英
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Co-author:
YuZhuqing,HanXiaofeng,HuangTinglin,ZhengJian
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First Author:
dongsheying
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Indexed by:
Journal paper
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Volume:
卷：25
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Issue:
期：6
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Page Number:
页：807~811
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Translation or Not:
no
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Date of Publication:
2009-12-01
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