Study on the interaction between clarithromycin and bovine serum albumin in the imitated physiology solution
- Release time:2024-08-09
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Affiliation of Author(s):
化学与化工学院
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Journal:
Chin. Chem. Lett
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Key Words:
中文关键字：克拉霉素;牛血清蛋白;相互作用;线性伏安扫描，英文关键字：Clarithromycin; Bovine serum albumin; Interaction;
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Abstract:
The interaction between clarithromycin (CAM) and bovine serum albumin (BSA) was investigated using linear-sweep voltammetry in pH 7.4 phosphate buffer solution where CAM caused two irreversible reduction waves P2 and P3 on mercury electrode. The study showed that the formation constant and formation ratio for the interaction between CAM and BSA were 1.51 × 1012 and 3:1 for P2, 4.53 × 105 and 1:1 for P3, respectively. The ion strength enhanced the hydrophobic interaction between CAM and BSA.
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Note:
SCI-E
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Co-author:
ChunxiaXue,TinglinHuang
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First Author:
dongsheying
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Indexed by:
Journal paper
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Volume:
卷：18
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Issue:
期：6
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Page Number:
页：726-729
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Translation or Not:
no
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Date of Publication:
2007-06-01
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