Research Progress in Cyanine-Based Recognition Probes for G-Quadruplex DNA
发布时间：2024-10-27
点击次数：
- DOI码：
- 10.6023/cjoc202203025
- 发表刊物：
- CHINESE JOURNAL OF ORGANIC CHEMISTRY
- 关键字：
- cyanine dye G-quadruplex DNA recognition probe molecular design
- 摘要：
- Guanine-rich (G) DNA sequences can form a special nucleic acid secondary structure called G-quadruplex DNA, which is widely distributed in eukaryotic genomes and is closely associated with the formation and development of cancer. The development of small molecule fluorescent probes targeting G-quadruplexes is of great significance for the study of the biological functions of G-quadruplexes in organisms and for targeting anti-cancer drugs. The cyanine dyes are widely used as fluorescent dyes for biolabelling, with the advantages of multiple modification sites and adjustable spectral range. The rigid structural part of the backbone can be bound to the end of the G-quadruplex or groove through p-p stacking, hydrophobic interaction and other non-covalent bonding, inducing different spectral signal changes of cyanine dyes to achieve selective recognition of the G-quadruplex. This has become a hot topic of research in the field of G-quadruplex recognition in recent years. Herein, the research progresses in the field of G-quadruplex recognition probes based on cyanine dye are reviewed. Molecular design and propertis of this kind of probes are briefly introduced, and the affinity and selectivity of probes for G-quadruplex DNA are also commented. Moreover, the future trends of cyanine-based recognition probes for G-quadruplex are briefly introduced.
- 合写作者：
- 毛永爆,周艳艳,冯潇雯
- 第一作者：
- 关丽
- 论文类型：
- 期刊论文
- 通讯作者：
- 付义乐
- 学科门类：
- 理学
- 文献类型：
- J
- 卷号：
- 42
- 期号：
- 8
- 页面范围：
- 2406-2417
- 是否译文：
- 否
- 发表时间：
- 2023-01-01
- 收录刊物：
- SCI